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"drug discovery"

Blood, Rats and Anticoagulants: The Story of Warfarin

The history of Warfarin is a surprisingly bloody one. Find out how this anticoagulant drug went from cow-killer to life-saver in this Nature Video animation. This video was reproduced with permission and was first published on March 13, 2018...

March 16, 2018 — Nature Video
New Vertex drug combination for cystic fibrosis represents a triumph of drug discovery research

New Cystic Fibrosis Medication a Triumph of Drug Discovery

Getting a drug from conception to market is among the riskiest, hardest and most expensive of scientific and human endeavors, often requiring up to ten years of effort and anywhere between 1 and 5 billion dollars...

June 28, 2014 — Ashutosh Jogalekar

(Don't) Mind the Gap: Manufacutring Costs and Drug Prices

Misleading statements and conclusions regarding drug costs and prices are again being thrown around. It started with a post right here on Scientific American Blogs with the title “The Quest: $84,000 Miracle Cure Costs Less Than $150 to Make”...

April 24, 2014 — Ashutosh Jogalekar
Physics envy: The last emotion you ever want to feel

Physics envy: The last emotion you ever want to feel

This is a guest post by my friend Pinkesh Patel, a data scientist at Facebook. Pinkesh has a PhD in physics from Caltech during which he worked on LIGO, the gravitational wave detector.

April 3, 2014 — Ashutosh Jogalekar
Why the new NIH guidelines for psychiatric drug testing worry me

Why the new NIH guidelines for psychiatric drug testing worry me

Psychiatric drugs have always been a black box. The complexity of the brain has meant that most successful drugs for treating disorders like depression, psychosis and bipolar disorder were discovered by accident and trial and error rather than rational design...

March 21, 2014 — Ashutosh Jogalekar
Why drug discovery is hard – Part 3: Vacuum cleaners that make Sir James Dyson weep

Why drug discovery is hard, part 3 – Vacuum cleaners that make Sir James weep

This is part 3 of a series of posts delving into the fundamental scientific challenges in drug discovery. Here are the other parts: 1, 2. Any number of thrillers or action movies should convince us that the first and most important stratagem in defeating an enemy is getting inside his fortress or camp...

January 10, 2014 — Ashutosh Jogalekar
Why drugs are expensive: It’s the science, stupid.

Why drugs are expensive: It’s the science, stupid.

This is part 1 of a series of posts delving into the fundamental scientific challenges in drug discovery. Often you will hear people talking about why drugs are expensive: it’s the greedy pharmaceutical companies, the patent system, the government, capitalism itself...

January 6, 2014 — Ashutosh Jogalekar
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