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A New Cell Map of the Human Heart

Scientists have created an atlas of cardiac cells in six regions that could help chart what goes awry in heart disease

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The human heart is an amazing organ. Its muscle cells must contract in exquisite synchrony to pump oxygenated blood throughout the body. Now scientists have created a detailed map of cells in six regions of the heart. “For the first time, we have a zip code for each cell to know what population it belongs to,” said Christine Seidman, a cardiovascular geneticist at Harvard University and director of the Cardiovascular Genetics Center at Brigham and Women’s Hospital, in a recent statement. Seidman, who is also an investigator at Howard Hughes Medical Institute, and her colleagues described the heart atlas in September in Nature.

Understanding these cells and their functions in a healthy heart could help them determine what goes wrong in heart disease, the world’s leading cause of death. This video shows a beating heart with a protein involved in muscle contraction labeled in green.

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Tanya Lewis was formerly senior desk editor for health and medicine at Scientific American. She wrote and edited stories for the website and print magazine on topics ranging from COVID to organ transplants. She also appeared on Scientific American’s podcast Science Quickly and wrote Scientific American’s weekly Health & Medicine newsletter. She held a number of positions over her nearly 10 years at Scientific American, including health editor, assistant news editor and associate editor at Scientific American Mind. Previously, she has written for outlets that include Insider, Wired, Science News and others. She has a degree in biomedical engineering from Brown University and one in science communication from the University of California, Santa Cruz. Follow her on Bluesky @tanyalewis.bsky.social

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