Every year, the hearts of millions of Central and South Americans are quietly damaged by parasites. During the night, insects called kissing bugs emerge by the hundreds from hiding places in people’s mud and stick homes to bite their sleeping victims. The bugs defecate near the punctured skin and wriggling wormlike parasites in this poop may enter the wound and head for their victims' hearts. There, in about a third of victims, they damage the organs for decades before causing potentially lethal heart disease. Around 12,000 people worldwide die each year from the ailment, called Chagas disease.

Scientists thought Americans were safe in their sturdier houses. Now some are not so sure. Chagas-infected kissing bugs do enter at least some southern U.S. dwellings and bite people living there, recent studies suggest. And a new study published two weeks ago raises the specter of Chagas from another more familiar insect pest: bed bugs, found all over the country. Biting bed bugs have been found to transmit the parasite between mice.

The bed bug effect has not been demonstrated yet among people but these studies have made some physicians and scientists wonder if they have underestimated the chance of acquiring Chagas in this country. “We are very likely missing [Chagas] cases,” said a May 2014 editorial in The American Journal of Medicine. “A systemic survey of the high-risk population in the U.S. is urgently needed.”

That’s a sentiment echoed by at least one CDC scientist. “We know that people are acquiring this infection in the United States. But it's not common,” says Susan Montgomery, epidemiology team lead of the Parasitic Diseases Branch at the CDC. Epidemiologists do know that eight million people in Central and South America and up to 300,000 U.S. immigrants are infected. “Can we interpret that to say we know a lot about this? No, we don't know much. We really need more studies to understand what the risk is,” Montgomery says.

Kissing bugs carrying Chagas are prevalent throughout the southern U.S. and 24 mammal species can act as reservoirs for the disease. Although it has long been known that kissing bugs carrying the Chagas parasite, which is called Trypanosoma. cruzi, conventional wisdom held that the bugs in the U.S. are repulsed by our well-sealed homes with solid walls and prefer to nest in animal burrows anyway. Until now only 23 cases of U.S.-acquired Chagas have been identified, the first recognized as early as 1955. But the flurry of new results hint the rarity of cases may have more to do with a lack of looking than a lack of disease. “There's a long history of positive bugs in the southern United States, and a long history of mammals being infected,” says Melissa Nolan Garcia, a research associate at Baylor College of Medicine's National School of Tropical Medicine who has studied southeastern Texas blood donors infected with T. cruzi. “It's just that we're not doing enough to look at actual humans.”

One actual human, a 74-year-old woman in rural New Orleans Parish, was found to have contracted Chagas from kissing bugs invading her home in 2006. The bugs had bitten her more than 50 times and left her walls and nightgown streaked with bug feces. Twenty dead bugs were found in her home and in an additional building on her property with a bed after fumigation and over half were infected with T. cruzi. Neither nymphs nor eggs were found in the house, indicating the bugs weren't even nesting there, but the home was 29 years old and had many gaps through which bugs could enter.

A year later, researchers collected an additional 49 kissing bugs from inside and around the outside of the woman’s home and found nearly half the bugs had fed on eight different humans. In the December 2014 issue of Emerging Infectious Diseases the scientists who made this discovery also reported that about 40 percent of all the bugs were infected with T. cruzi and three of the humans had been bitten by infected bugs. According to Garcia, those most likely at risk of contracting Chagas in the U.S. are outdoor enthusiasts in the South and Southwest, along with people living in “substandard” homes with many cracks and crevices permitting bug entry.

More evidence of human infection has emerged from studies of U.S. blood donors, whose donations have been tested for T. cruzi since 2007. In the last two years small studies have revealed that 7.5 percent of a national sample of Chagas-positive blood donors and 36 percent of a sample of donors from southeastern Texas seemed likely to have acquired their infections here in the U.S. Although blood donor samples may be biased in ways that make them poor representatives of the wider population, some researchers suggest blood donors may actually underrepresent infections: Poor or sick people—the most vulnerable to the parasite—may be less likely to donate.

Then late last month scientists announced they have shown that bed bugs carrying T. cruzi can transmit the infection to laboratory mice via infected feces deposited near a bite wound. Not only did the bugs infect mice, clean bugs also picked up the parasite from infected mice.

The bed bug population in U.S. homes has skyrocketed in the last 10 years, and it's possible—although still not demonstrated—that immigrants or others who already have T. cruzi could infect bed bugs in their home who could then pass it to other people in the household, says Michael Levy, assistant professor of epidemiology at the University of Pennsylvania Perelman School of Medicine and a co-author of the study. Much more worrisome, he says, is the possibility that bed bugs may also feed on rodents in homes, which may act as a reservoir species for T. cruzi. Whether that happens or could happen is also currently unknown.

For now the evidence is stronger that kissing bugs are a bigger Chagas threat in the U.S. Surveys of wild U.S. kissing bugs have begun to show that contrary to conventional wisdom, the insects can and do commonly feed on humans. One Texas study found that 73 percent of 40 kissing bugs collected near homes in central and southern Texas carried Chagas, and half of those had fed on humans. A study of kissing bugs from a wildlife park in Arizona found that nearly all of the bugs had fed on humans, and about a quarter harbored the parasite. Because no people live permanently at the park, the authors concluded that free-roaming U.S. kissing bugs could feed like mosquitoes on active people outside of homes.

And those outdoor bugs may be drawn into houses. According to research published in PLoS ONE, Clinical Infectious Diseases and The American Journal of Medicine, during their spring and summer dispersal kissing bugs attracted to lights enter homes in the southwest and may feed on homeowners and pets for months, sometimes provoking allergic reactions. In Bisbee, Ariz., according to the authors of the Arizona wildlife park study, kissing bugs seem to have become domesticated and are “resident throughout the year in older houses and feed regularly on humans with all life stages present in the homes”.

Yet the reality is that health officials just don't know how many Americans may have already acquired Chagas within the U.S. The symptoms mimic what is already America's number-one killer: heart disease, making the disease difficult to diagnose.

Garcia has submitted applications for grants to fund two studies—one to look at people with heart failure of unknown cause and another to expand blood donor studies across the South. Other ideas for getting a better handle on the true burden of U.S.-acquired Chagas cases include doing broad blood surveys of all people—not just blood donors—living in suspected high-risk areas and identifying what behaviors are associated with infection.

That kind of data should help, other researchers say. “I think there's information we need before we can actually quantify how concerned we should be,” says Caryn Bern, professor of epidemiology and biostatistics at the University of California, San Francisco, School of Medicine who has studied T. cruzi and Chagas extensively and previously worked for the CDC. “Certainly it's there. Certainly transmission is occurring.”