The song "Don't Worry, Be Happy," could double as sound medical advice, the results of a new study suggest. Whereas previous research had linked depression with an increased incidence of health problems, the new findings reveal that people who report more everyday happiness are healthier overall than their less joyous counterparts in a number of key ways. In particular, happy men experienced lower heart rates throughout the day, indicating good cardiovascular health.

Andrew Steptoe and his colleagues at University College London studied the emotional and physical well-being of more than 200 middle-aged Londoners recruited for the Whitehall II psychobiology study in the mid-1980s. The participants underwent stress tests, along with blood pressure and heart rate monitoring, and they were asked to record their feelings of happiness throughout their daily lives. The team found that those people who reported feeling happier more often also had on average lower levels of the stress hormone cortisol, which is linked with hypertension and type II diabetes, than did people who recounted fewer moments of joy.

In addition, content subjects performed better under stressful conditions in a laboratory task and showed fewer ill aftereffects. Following the assignment, they exhibited lower levels of a blood protein called fibrinogen, which at high levels can indicate potential cardiovascular problems. The findings are published online this week by the Proceedings of the National Academy of Sciences.