The prime mosquito suspect for bird-to-human transmission of WNV is Culex pipiens, a complex of species that live throughout the world. In northern Europe, one strain of Cx. pipiens lives aboveground and another swarms in sheltered underground environments, such as subway tunnels. The aboveground strain gets its blood meals from birds; the underground strain prefers to feed on humans. Geneticist Dina M. Fonseca of the Smithsonian Museum of Natural History and her colleagues compared the genomes of these underground and aboveground populations to Cx. pipiens from other parts of the world, including the U.S. The northern European insects turned out to be genetically distinct from each other, with underground human-biters more closely resembling mosquitoes from warmer southern locales. But more than 40 percent of the U.S. mosquitoes tested genetically resembled both of the northern European groupsthat is, they appeared to be hybrids of the two.
Why the hybrids are so common in the U.S. but virtually absent in northern Europe "is a big mystery to us," says study co-author Robert C. Fleisher, also at the Smithsonian. No one knows whether they arrived from warmer climates in southern Europe, or emerged when northern European aboveground and underground individuals arrived here in the U.S. and mingled, but "theres some reason why the reproductive barrier broke down," Fleisher remarks. Observation of the behavior of the mosquitoes themselves may bring answers. Specifically, determining why open-air and subterranean Cx. pipiens do not reproduce in northern Europe and finding out how often individual mosquitoes bite a bird and then a human could illuminate how the virus is transmitted.
Meanwhile, although northern Europeans remain largely untouched by WNV, the new findings highlight how flux in mosquito genetics can affect the spread of the disease. Indeed, the authors conclude that "the arrival of hybrid American forms in northern Europe has the potential to radically change the dynamics of WNV infection in Europe." --Alla Katsnelson