New Issue: Orbital Catastrophe Ahead? Read Now

Ice Bucket Challenge Credited with ALS Breakthrough

The fundraising campaign raised $220 million worldwide 

Join Our Community of Science Lovers!

By Reuters Staff

(Reuters) - The Ice Bucket Challenge that went viral two years ago, raising hundreds of millions of dollars, has helped identify a new gene behind the neurodegenerative disease ALS, or Lou Gehrig's disease, researchers say.

The challenge involved people pouring ice-cold water over their heads, posting video on social media, and donating funds for research on the condition.


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Celebrities including Taylor Swift, Kim Kardashian, Ellen DeGeneres, Benedict Cumberbatch and former U.S. President George W. Bush were among millions of people who took part in 2014, attracting more than 400 million views on social media.

The challenge raised $220 million worldwide, according to the Washington-based ALS Association. News of the gene discovery again sent Ice Bucket Challenge viral, proving one of the top trending topics on Twitter on Wednesday.

The money funded the largest ever study of inherited ALS and identified a new gene, NEK1, that ranks among the most common genes that contribute to amyotrophic lateral sclerosis, the ALS Association said in a statement on Monday.

"Global collaboration among scientists, which was really made possible by ALS Ice Bucket Challenge donations, led to this important discovery," said John Landers of the University of Massachusetts Medical School. Landers and Jan Veldink of University Medical Center Utrecht led the study involving researchers in 11 countries.

"It is a prime example of the success that can come from the combined efforts of so many people, all dedicated to finding the causes of ALS," Landers said in a statement.

The research was published in the scientific journal Nature Genetics this week and scientists hope it will provide another potential target for therapy development.

Subscribe to Support Independent Journalism

Great science journalism requires human expertise, time, effort and creativity. And it costs money. That’s why I and the journalists here at Scientific American hope you’ll join our community.

When you subscribe, you are supporting staff and freelance journalists who are passionate about telling science stories that are true, important and compelling. Our editors and reporters are often experts in their fields, which means they understand the nuances of big discoveries and can untangle the breakthroughs from the hype. With a subscription, you are also supporting rigorous fact-checking to ensure the words we publish are precise and accurate. And you’re supporting original illustrations, graphics and photos that bring you closer to an advanced laboratory, an ice sheet in Antarctica or a space mission in orbit. You’re helping us craft other types of high-quality journalism as well: Our newsletters are carefully written, edited and curated by staffers you have or will come to know and love. Our Science Quickly podcast is based on original reporting, collaboration with editors and scientists and exacting production.

Subscriptions keep this engine running so we can continue to deliver thoughtful, rigorous and independent science journalism to you. In an era of viral misinformation, this work is crucial. If you value what we do, I hope you’ll consider joining us as a subscriber

Thank you,

Jeanna Bryner, Editor in Chief, Scientific American

Subscribe