Loneliness Predisposed

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


If you feel lonely persistently, blame it partly on your genes. In a survey of 8,387 siblings, 48 percent of identical twins and 24 percent of fraternal twins reported similar levels of moderate to extreme loneliness, with much higher agreement than siblings who were not twins. The results come from a 12-year study done in the Netherlands by psychologists at Free University and the University of Amsterdam and at the University of Chicago.

The findings, along with ongoing investigation of a satellite of proximal genes on chromosome 12, suggest that some individuals have a genetic vulnerability to feelings of loneliness. Such a propensity should not, however, be thought of as an immutable trait, such as eye color, says psychology professor John T. Cacioppo of the University of Chicago. Rather the genetic bent should be viewed as a risk factor that makes certain individuals more sensitive to environmental factors that can cause loneliness.

Because loneliness is associated with medical conditions such as elevated blood pressure, knowing your inherited predisposition to it could allow you to make better health decisions. For instance, “you might not take that promotion that requires you to move across the country and leave friends and family behind,” Cacioppo notes.

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe