A Toxic Cascade: When the Brain Consumes Itself [Slide Show]
In the brain, bent-out-of-shape proteins can cause devastating neurological diseases
By Gary Stix
On supporting science journalism
If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.
In recent years neuroscientists have come upon an astonishing revelation: Alzheimer’s, Parkinson’s, Lou Gehrig’s and other major brain diseases may have a similar underlying cause. They may all result from the mis-folding of proteins in a process similar to the one linked to mad cow and other prion-based diseases. The growing number of research findings that point to this conclusion are set out in “Seeds of Dementia,” by Lary C. Walker and Mathias Jucker in the May issue. The accompanying slide show illustrates this cascading process of one protein corrupting another, leading to the buildup of toxic aggregations, which underlie diseases that cause brain cell degeneration.
» View the Toxic Cascade Slide Show
It’s Time to Stand Up for Science
If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.
I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.
If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.
In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.
There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.
