Anthony Fauci, who has been the top infectious-diseases adviser in the United States for almost 40 years, announced on 22 August that he would resign from his leadership roles in December. Although many scientists are saddened to be losing his guidance, they understand his desire to step down. No other federal scientist has held a top position for as long as Fauci.

“Dr Fauci is the most dedicated public servant I have ever known,” says former US National Institutes of Health (NIH) director Francis Collins, who has worked closely with Fauci over the years. “His contributions have saved countless lives from HIV/AIDS, Ebola and SARS-CoV-2, and will stand as profoundly significant gifts to humanity.”

US President Joe Biden, who elevated Fauci to the role of his top medical adviser, echoed Collins’s sentiments. “His commitment to the work is unwavering, and he does it with an unparalleled spirit, energy, and scientific integrity,” Biden said. As vice-president, Biden worked with Fauci on the US response to outbreaks of the Zika and Ebola viruses.

Researchers who Nature spoke to say that Fauci will be best remembered for his unwavering dedication to research and the development of treatments for HIV, as well as for his uncanny ability to communicate directly and clearly to the public. Whenever there was a particularly concerning public-health emergency, “the government would trot out their best weapon — Tony Fauci”, says Jennifer Nuzzo, an epidemiologist at Brown University in Providence, Rhode Island. She joked with colleagues that whether a pathogen was worth worrying about was clear from the number of times Fauci appeared on television, nicknaming the phenomenon the ‘Tony Fauci index’.

‘Determined and aggressive’ efforts

Fauci has been at the helm of the US National Institute of Allergy and Infectious Diseases (NIAID) in Bethesda, Maryland, under seven US presidents, starting with Ronald Reagan in 1984. Most recently, he became the face of the US response to the COVID-19 pandemic and a trusted voice worldwide who helped millions to make sense of a rapidly evolving threat. During his tenure, he transformed the NIAID from a lesser-known NIH institute with an annual budget of US$350 million to a global role model in infectious-diseases research with a budget exceeding $6 billion a year.

Fauci is one of the most highly cited scientists of all time on account of his work on HIV immunology and has been well known in the infectious-diseases research community for decades. However, his role as a leading expert has, at times, been tumultuous. During the AIDS epidemic in the 1980s and early 1990s, activists felt that the NIAID’s clinical trials were moving too slowly to help people with HIV gain access to life-saving therapies that were still being tested. They blamed Fauci for what they saw as unnecessary deaths, and staged protests in front of his office. Fauci began a dialogue with the activists that led, within years, to the development of effective treatments to suppress the virus that would become the global standard of care. This type of collaboration with the community was unprecedented and became a model for future health-care leaders, says Steven Deeks, an HIV clinician at the University of California, San Francisco. “But Tony was the first,” he says.

Working with former president George W. Bush, Fauci also helped to design the US President’s Emergency Plan for AIDS Relief (PEPFAR), a global programme launched in 2003 to provide treatment for people with HIV. PEPFAR, which is probably Fauci’s greatest and most impactful accomplishment, Deeks says, has “unequivocally saved millions of lives”. Bush awarded Fauci the Presidential Medal of Freedom in 2008 for his “determined and aggressive efforts”.

In 2014, at a time when people were worried about whether the Ebola outbreak in West Africa would become a pandemic, Fauci helped treat and notably hugged a nurse who had been infected with the virus and hospitalized at the NIH. Fauci later said he did this to show his staff that he wouldn’t ask them to do anything that he wouldn’t do himself. That “extraordinary level of empathy” will be difficult to replace, Nuzzo says.

Fast forward to 2020, and Fauci once again came under fire — this time from the president whom he was serving. Dissatisfied with Fauci’s guidance to curb the SARS-CoV-2 coronavirus’s spread by implementing interventions such as mask wearing and social distancing, former president Donald Trump attempted to silence Fauci by, at times, preventing him from speaking publicly. Trump also hinted that he might fire Fauci (Fauci is a civil servant in the US government, not a political appointee, so it is not clear how Trump might have done this). Fauci has received death threats and has had federal guards overseeing his safety.

“Because of the sustained attacks on him and failure of our political leaders to rebuke those attacks, his ability to communicate was lessened,” Nuzzo says.

The next generation

Although in announcing his departure Fauci did not detail his future plans, he was clear that he would not be retiring. “I plan to pursue the next phase of my career while I still have so much energy and passion for my field,” he wrote. He indicated that whatever he does next, it will involve advancing science and public health, and mentoring the next generation of science leaders.

Fauci’s mentorship has helped to shape countless scientists — including Akiko Iwasaki, an immunologist at Yale University in New Haven, Connecticut — to be the scientists they are today. Although Iwasaki says she was just a “lowly postdoc” at the NIH in 1998, Fauci took time out of his schedule to meet with her on several occasions. “He has this way of elevating scientists around him,” she says.

The NIAID did not respond to an e-mail enquiring about when Fauci’s replacement might be named. But Deeks hopes the new director will have the same desire to continue trying to end the HIV epidemic. “Tony has carried this on his shoulders for 40 years,” he says.

This article is reproduced with permission and was first published on August 22 2022.