New Issue: Orbital Catastrophe Ahead? Read Now

A Simpler Origin for Life

The sudden appearance of a large self-copying molecule such as RNA was exceedingly improbable. Energy-driven networks of small molecules afford better odds as the initiators of life

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Extraordinary discoveries inspire extraordinary claims. Thus, James Watson reported that immediately after he and Francis Crick uncovered the structure of DNA, Crick "winged into the Eagle (pub) to tell everyone within hearing that we had discovered the secret of life." Their structure--an elegant double helix--almost merited such enthusiasm. Its proportions permitted information storage in a language in which four chemicals, called bases, played the same role as 26 letters do in the English language.

Further, the information was stored in two long chains, each of which specified the contents of its partner. This arrangement suggested a mechanism for reproduction: The two strands of the DNA double helix parted company, and new DNA building blocks that carry the bases, called nucleotides, lined up along the separated strands and linked up. Two double helices now existed in place of one, each a replica of the original.

About Robert Shapiro

is professor emeritus of chemistry and senior research scientist at New York University. He is author or co-author of over 125 publications, primarily in the area of DNA chemistry. In particular, he and his co-workers have studied the ways in which environmental chemicals can damage our hereditary material, causing changes that can lead to mutations and cancer. In 2004, he was awarded the Trotter Prize in Information, Complexity and Inference. Shapiro has written four books for the general public: Life Beyond Earth (with Gerald Feinberg); Origins, a Skeptic's Guide to the Creation of Life on Earth; The Human Blueprint (on the effort to read the human genome); and Planetary Dreams (on the search for life in our Solar System). When he is not involved in research, lecturing or writing, he enjoys running, hiking, wine-tastings, theater and travel. He is married and has a 35-year-old son.

More by Robert Shapiro
Scientific American Magazine Vol 296 Issue 6This article was published with the title “A Simpler Origin for Life” in Scientific American Magazine Vol. 296 No. 6 ()
doi:10.1038/scientificamerican062007-4b0dXtmQNU8Io6b9ohJJuL

Subscribe to Support Independent Journalism

Great science journalism requires human expertise, time, effort and creativity. And it costs money. That’s why I and the journalists here at Scientific American hope you’ll join our community.

When you subscribe, you are supporting staff and freelance journalists who are passionate about telling science stories that are true, important and compelling. Our editors and reporters are often experts in their fields, which means they understand the nuances of big discoveries and can untangle the breakthroughs from the hype. With a subscription, you are also supporting rigorous fact-checking to ensure the words we publish are precise and accurate. And you’re supporting original illustrations, graphics and photos that bring you closer to an advanced laboratory, an ice sheet in Antarctica or a space mission in orbit. You’re helping us craft other types of high-quality journalism as well: Our newsletters are carefully written, edited and curated by staffers you have or will come to know and love. Our Science Quickly podcast is based on original reporting, collaboration with editors and scientists and exacting production.

Subscriptions keep this engine running so we can continue to deliver thoughtful, rigorous and independent science journalism to you. In an era of viral misinformation, this work is crucial. If you value what we do, I hope you’ll consider joining us as a subscriber

Thank you,

Jeanna Bryner, Editor in Chief, Scientific American

Subscribe