Stress on the Brain

Researchers have for the first time observed the effects of psychological stress on the human brain.

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Researchers have for the first time observed the effects of psychological stress on the human brain. In the study, scientists used functional magnetic resonance imaging (fMRI) to spy on the brains of subjects who were asked to complete challenging arithmetic exercises while being monitored. The team also took note of the participants' emotional responses and changes in their stress hormone levels and heart rate; many reported feeling flustered and upset by the task. The imaging results showed increased blood flow to the brain's prefrontal cortex, an area known to be associated with anxiety and depression, but also its ability to perform executive functions that allow humans to cope with environmental challenges and threats. Furthermore, the increased blood flow continued even after completion of the math problems. According to the team, the results suggest that although stress may enhance focus, too much of it may be damaging to mental health. The findings are to be published online this week by the Proceedings of the National Academy of Sciences.

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe