We should all be worried by the growing number of antibiotic-resistant bacteria and we urgently need to develop new drugs, Ada Yonath told attendees at this summer’s Lindau Nobel Laureates meeting in Germany. Participating laureates and young researchers came from all over the world to discuss chemistry this year. Yonath and Brian Kobilka won Nobel Prizes for using x-ray crystallography to understand cell structures that are vital targets for drug development. In this film, three researchers challenge the structural approach and propose alternative ways to find drugs; some cutting edge, such as computation, and some ancient, such as searching for chemicals deep in the rain forest. What is the best way forward? Or is a combination of techniques the most promising approach?