A suspected outbreak of infections with hantavirus, a pathogen that causes rare and deadly diseases, on a cruise ship that is currently off West Africa has killed three people and sickened at least three more.
The first fatality—a Dutch man—occurred on April 11, although no cause of death could be determined at the time. His wife later fell ill and also died, while a German national died on the ship on May 2. Hantavirus is believed to have infected a further three people who were traveling on the ship, including one who is now in intensive care in South Africa. One case of the infection has been confirmed in a laboratory, according to the World Health Organization (WHO).
The cruise ship at the center of the outbreak is the MV Hondius, operated by Oceanwide Expeditions; some 150 passengers remain onboard. As of Monday morning, Oceanwide said in a statement that so far hantavirus infection has only been confirmed in the person receiving treatment in South Africa and that local health authorities had visited the ship but have not yet approved the disembarkation of passengers or the medical evacuation of two crew members who have fallen ill.
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“Preparations are being made for possible medical repatriation and next steps,” the company said in the statement. “Oceanwide Expeditions is in close contact with those directly involved and their families, and is providing support where possible.” The company did not immediately respond to a request for further comment.
What is hantavirus?
Hantaviruses are a family of viruses that are primarily spread through contact with rodents, such as rats and mice, and particularly through exposure to the animals’ urine, droppings and saliva, according to the U.S. Centers for Disease Control and Prevention. Generally, people breathe in one of these viruses when particles of rodent feces or urine are disturbed. The infection may also spread from person to person, according to the CDC; it’s unclear whether the ongoing outbreak is an example of that happening. The only type of hantavirus that is known to have spread from one person to another is the Andes virus, which occurs in South America.
Infections typically map onto two syndromes—hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome.
The mortality rate for hantavirus pulmonary syndrome is 38 percent. Symptoms usually start to present one to eight weeks after exposure to the pathogen and can include fatigue, fever and muscle aches, while about half of all infected people can also experience headaches, dizziness, chills, nausea, vomiting, diarrhea and abdominal pain. Within four to 10 days of the initial symptom onset, people typically start coughing and experiencing shortness of breath while their lungs fill with fluid. The disease caused the death of the late actor Gene Hackman’s wife, Betsy Arakawa, in February 2025, officials in New Mexico said last year.
Hemorrhagic fever with renal syndrome, meanwhile, has several different forms, with mortality rates varying from 1 percent to 15 percent. Symptoms can include intense headaches, back and abdominal pain, fever and chills, nausea and blurred vision. As the disease progresses, new symptoms can arise, including low blood pressure, lack of blood flow, internal bleeding and acute kidney failure.
Diagnosing the disease early in the course of an infection is hard, particularly because of the early symptoms’ similarities to influenza. And treatment is also difficult: there are no known cures, though the drug ribavirin has shown signs of reducing mortality. Antivirals and other supportive interventions may help manage symptoms, but preventing an infection is key.
In the U.S., hantavirus that causes hantavirus pulmonary syndrome is most commonly spread by the deer mouse, according to the CDC. The agency recommends that you limit contact with rodents at home or in any enclosed space to help reduce the risk of the disease and wear protective gear such as an N95 mask and gloves if you have to clean up after any rodents.
Editor’s Note (5/4/26): This is a developing story and may be updated.
