Cell Studies Could Lead to Anti-Aging Drugs
Researchers have uncovered an ancient mechanism that retards aging. Drugs that tweaked it could well postpone cancer, diabetes and other diseases of old age
Stories by David Stipp
Can Fasting Slow Aging?
Intermittent fasting might improve health, at least according to research in animals
Beyond Resveratrol: The Anti-Aging NAD Fad
Whenever I see my 10-year-old daughter brimming over with so much energy that she jumps up in the middle of supper to run around the table, I think to myself, “those young mitochondria.” Mitochondria are our cells’ energy dynamos.
How Anti-Aging Drugs Could Help Medicare
When Google recently announced that it had formed a company, Calico, to tackle the challenge of aging and associated diseases, it said little about what the new spinoff would do.
Thinning the Fog around Sirtuins
What is it about sirtuins? Few research topics have engendered fiercer controversy in recent years than these enzymes, channels through which the famous red-wine ingredient resveratrol appears to exert effects like those of calorie restriction, a reduction of food intake known to slow aging in many species.The most basic bone of contention is whether resveratrol really activates sirtuins.
How Intermittent Fasting Might Help You Live a Longer and Healthier Life
Intermittent fasting might improve health, but clinical data are thin
How Senescent Cells Spur Aging and Cancer
Cells that permanently stop dividing have long been recognized as one of the body's defenses against cancer. Now they are also seen as a sometime culprit in cancer and a cause of aging
Naked Mole Rats Offer Clues to Living Longer
These creatures live more than five times longer than would be expected for their size. Research into the biological mechanisms underlying their longevity could suggest ideas for slowing aging in people
![Does This Animal Live Unusually Long? [Slide Show]](https://static.scientificamerican.com/sciam/cache/file/9CE63642-1425-44E9-89D1BCD3F8499DAE_agenda.jpg?w=275&h=154&fit=crop)
Does This Animal Live Unusually Long? [Slide Show]
An index called the longevity quotient indicates whether a species has an average life span or is unusually long-lived or short-lived for an animal of its size. A score of 1 is average; higher numbers reflect unusual longevity
Quest for Anti-Aging Drugs Transitions from Flaky to Mainstream
Image by Quentin Stipp, with permission. When I give talks on aging research someone usually asks, “When will scientists develop true anti-aging drugs?” My answer has little to do with what’s happening in the lab, though—it’s about politics, perceptions and money.It has been clear for many years that the rate of aging is malleable in diverse species, and the discovery in 2009 that a drug called rapamycin can extend maximum life span in mice suggested that it’s now technically feasible to develop anti-aging agents that really work as advertised.
A New Path to Longevity
Researchers have uncovered an ancient mechanism that retards aging. Drugs that tweaked it could well postpone cancer, diabetes and other diseases of old age
