
How Cancer Arises
An explosion of research is uncovering the long-hidden molecular underpinnings of cancer -- and suggesting new therapies

How Cancer Arises
An explosion of research is uncovering the long-hidden molecular underpinnings of cancer -- and suggesting new therapies

To sequence or not to sequence

Finding the Anti-Oncogene
Inheritance of certain growth-suppressing genes in a mutated form confers susceptibility to cancer. The first such gene to be isolated gives rise to a predisposition to retinoblastoma, an eye tumor

The Molecules of Life
Introducing an issue about the new biology, which seeks to explain the molecular mechanisms underlying biological complexity. It has given rise to an industry, and to new ways of thinking about life

A Molecular Basis of Cancer
Human cancers are initiated by oncogenes, altered versions of normal genes. In one case the critical alteration is a single point mutation that changes just one amino acid in the protein encoded by the gene