Slight changes around the eyes are indeed a giveaway as to whether a smile is sincere or faked.

Is that person really glad to see me? Or are they just being polite? Some people struggle to distinguish a perfunctory grin from a truly happy smile. And computers have found this task even more difficult—that is, until researchers trained a program to detect when a smile is genuine.
Visual computing researchers at the University of Bradford in the U.K. started with software for analyzing a changing facial expression. This program can examine a video clip of a human head and identify specific details around the eyes, cheeks and mouth. Then the program tracks the details moving relative to each other as the face smiles.
Next, the scientists had their program evaluate two sets of video clips. In one, subjects performed posed smiles. In the other, they watched a film that inspired genuine displays of emotion. The program calculated the differences among the subjects’ faces during the two clips. And it turns out that your mouth, cheeks and eyes move differently when you’re faking that smirk.
In particular, the muscles around the eyes shift 10 percent more for a real smile than they do for a fake one. These results are in the journal Advanced Engineering Informatics. [Hassan Ugail and Ahmad Al-dahoud, A genuine smile is indeed in the eyes—The computer aided non-invasive analysis of the exact weight distribution of human smiles across the face]
The researchers suggest their work could improve a computer’s ability to analyze facial expressions and thus to interact more smoothly with humans. But their real accomplishment is in proving Tyra Banks right: “You have to smile with your eyes.”
—Sophie Bushwick
[The above text is a transcript of this podcast]