Diabetes Prevention in Midlife Helps Protect Aging Brain

People with type 2 diabetes in middle age had greater cognitive impairment in the following decades than did their nondiabetic counterparts. Dina Fine Maron reports
 

Join Our Community of Science Lovers!


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Want to ward off memory issues and other cognitive problems as you age? Looks like low blood glucose levels are an important factor. New research finds that individuals diagnosed with type 2 diabetes in middle age had greater cognitive impairment in the following decades than their nondiabetic counterparts.

In fact, poorly managed diabetes appears to age the brain roughly five years faster than normal. That means a 55-year-old with diabetes has cognitive decline on par with a healthy 60-year-old. And the problems accumulate: over 20 years, diabetes in midlife is associated with a 19 percent decrease in mental function. Cognitive decline is considered a precursor to dementia. The findings are in the journal Annals of Internal Medicine. [Andreea M. Rawlings et al, Diabetes in Midlife and Cognitive Change Over 20 Years: A Cohort Study]

A team from Johns Hopkins Bloomberg School of Public Health followed some 6,000 study subjects in Maryland, North Carolina, Minnesota and Mississippi from 1987 through 2013. The researchers used accepted tests to evaluate the participants’ cognitive performance. And the people with low blood sugar levels outperformed those with midlife diabetes or pre-diabetes.   
 
The researchers’ conclusion: better weight control, exercise and a healthful diet could really help keep both body—and mind—fit over the long haul.
 
—Dina Fine Maron
 
[The above text is a transcript of this podcast.]

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe