Different Placebos Can Have Different Effects

In a study of patients asked to tolerate discomfort, different placebo treatments achieved different levels of relief, in keeping with individual expectations. Katherine Harmon reports

Join Our Community of Science Lovers!

When it comes to providing pain relief, expectations can be a powerful prescription. That’s part of the theory behind the placebo effect, in which people often report feeling better—even after a sugar pill or sham procedure—simply because they expect improvement.

Now a study finds that there may be levels of placebo effect.

Forty-five healthy volunteers had a heating electrode placed on their skin to cause discomfort. Over multiple sessions, they were either given nothing, or Tylenol, or needle-free acupuncture or electro-acupuncture, in which the needles carry a slight current.


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Painkillers should let them tolerate the heat longer. The hitch was that the Tylenol and needle-free conventional acupuncture were fakes.

The subjects were later interviewed about their expectations. And their feelings about each treatment largely determined its effect. Those who thought the acupuncture would work were more likely to report pain reduction from both the real and fake acu-treatments. The findings are in the journal PLoS ONE. [Jian Kong et al., Are All Placebo Effects Equal? Placebo Pills, Sham Acupuncture, Cue Conditioning and Their Association]

They suggest a variable placebo effect, one that may depend on whether you swallow that sugar pill with a grain of salt.

—Katherine Harmon

[The above text is a transcript of this podcast.]

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe