Fiber-Munching Mice Avoid Asthma

Mice fed a fiber-rich diet were more resistant to allergy-induced airway inflammation, thanks to happy gut bacteria that produce fatty acids, which calm the immune system. Sophie Bushwick reports

Illustration of a Bohr atom model spinning around the words Science Quickly with various science and medicine related icons around the text

Join Our Community of Science Lovers!

It's important to trust your gut. Because the stomach, and the food put into it, can influence the entire body. For example, a new study finds that mice that eat lots of fiber have stronger resistance against asthma-like attacks.

For two weeks, lab mice ate one of three diets: low-fiber, or regular chow, or food supplemented with fiber-rich pectin. Then the mice were exposed to allergy-inducing dust mites. And the low-fiber rodents suffered from increased airway inflammation, while the high-fiber group experienced less of an asthmatic response.

Seems that fiber supports gut bacteria that produce anti-inflammatory molecules called short chain fatty acids. These molecules then enter the bloodstream, where they can influence the immune system. An over-reactive immune system can play a role in allergies and asthma. But the fatty acids can calm down the immune reaction. The work is published in Nature Medicine. [Aurélien Trompette et al., Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis]


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


Directly injecting the mice with a short chain fatty acid had a similar anti-inflammatory effect. But mice probably prefer fiber to a series of shots—and it still helps them breathe easy.

—Sophie Bushwick

[The above text is a transcript of this podcast.]

[Scientific American is part of Nature Publishing Group.]

 

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe