Gut Bugs Affect Brains

A study with mice finds that the types of intestinal bacteria an individual carries can influence behavior. Karen Hopkin reports

Illustration of a Bohr atom model spinning around the words Science Quickly with various science and medicine related icons around the text

Join Our Community of Science Lovers!

Your digestive tract is home to about a trillion bacteria. And they pay rent. They protect you from infection, they harvest energy for you from what you eat and, if researchers are right, they affect your mental health as well. Because a new study shows that the bacteria that live in your intestines can influence your emotions and behavior. The work appears in the journal Gastroenterology. [Premysl Bercik et al., "The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice"]

Scientists found that treating adult mice with oral antibiotics not only messed with the balance of bugs in their bellies, but it changed their brain chemistry and behavior. The normally timid critters became less cautious and less anxious, perhaps because the gut bacteria influenced a boost in a protein that promotes neural growth. And taking the mice off the drug restored their original intestinal balance and behavior.

To confirm that the bacteria themselves were responsible, the scientists took mice that were raised in germ-free cages, animals that also happened to be naturally passive, and fed them bacteria from mice that were more active and daring. Sure enough, the newly infected mice grew more energetic and bold. So if you react to someone in a hostile way, you might literally be giving them a bellyful.


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


—Karen Hopkin

[The above text is an exact transcript of this podcast.]

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe