Surgeons Try Cold Cutting for Critically Injured
A clinical trial tests whether induced hypothermia can allow surgeons to save critically wounded patients who would not survive surgery at normal temperatures. Erika Beras reports
By Erika Beras

SUBSCRIBE TO Science Quickly
On supporting science journalism
If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.
On rare occasions, a swimmer can survive a near-drowning because cold water has protected their brains—even if they were submerged for up to an hour. Now a clinical trial is testing whether extreme cold can save critically injured gunshot and knife wound patients.
It’s called the Emergency Preservation and Resuscitation for Cardiac Arrest from Trauma Study. Lead Surgeon Sam Tisherman at the University of Pittsburgh Medical Center explains that patients are not declared dead, but:
“They’d be close. They’re in cardiac arrest and certainly if we can’t get a pulse back they’d be dead. But we’re not waiting to the point where the surgeons would declare them dead. We’re trying to do this right before this, and find the best window of opportunity where our standard of care hasn’t worked but it’s not too late to try something new.”
Surgeons will cool the patients’ bodies to 50 degrees by pumping dozens of liters of cold saline into the heart. This induced hypothermia nearly halts all activity in the body and brain.
By freezing patients, the surgeons will also freeze time—giving them the opportunity to repair wounds a warm patient wouldn’t typically survive. Should the procedure prove effective, it could give a new meaning to the phrase “cold comfort.”
—Erika Beras
[The above text is a transcript of this podcast.]
Subscribe to Support Independent Journalism
Great science journalism requires human expertise, time, effort and creativity. And it costs money. That’s why I and the journalists here at Scientific American hope you’ll join our community.
When you subscribe, you are supporting staff and freelance journalists who are passionate about telling science stories that are true, important and compelling. Our editors and reporters are often experts in their fields, which means they understand the nuances of big discoveries and can untangle the breakthroughs from the hype. With a subscription, you are also supporting rigorous fact-checking to ensure the words we publish are precise and accurate. And you’re supporting original illustrations, graphics and photos that bring you closer to an advanced laboratory, an ice sheet in Antarctica or a space mission in orbit. You’re helping us craft other types of high-quality journalism as well: Our newsletters are carefully written, edited and curated by staffers you have or will come to know and love. Our Science Quickly podcast is based on original reporting, collaboration with editors and scientists and exacting production.
Subscriptions keep this engine running so we can continue to deliver thoughtful, rigorous and independent science journalism to you. In an era of viral misinformation, this work is crucial. If you value what we do, I hope you’ll consider joining us as a subscriber