New Issue: Orbital Catastrophe Ahead? Read Now

Whitening Strips Alter Proteins in Teeth

Hydrogen peroxide in whitening treatments penetrates enamel and dentin, and alters tooth proteins. Christopher Intagliata reports.

Illustration of a Bohr atom model spinning around the words Science Quickly with various science and medicine related icons around the text

Join Our Community of Science Lovers!

Of all the stuff you can buy on eBay, here's a new one: human teeth. "I think I probably averaged maybe $5 a tooth." Kelly Keenan, a biochemist at Stockton University in New Jersey. 

Keenan chased down the chompers to investigate what whitening strips do to a tooth's chemical composition. So she stuck the teeth in styrofoam, applied the whitening strips per manufacturer instructions and added some artificial saliva: a liquid mixture at the pH and with salts you'd find in regular spit. 

Treatments complete, she extracted proteins from the teeth and found that the more rounds of whitening the teeth experienced, the fewer proteins she could recover—because hydrogen peroxide in the whitening strips was snipping chemical bonds.


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


"The bigger picture is that hydrogen peroxide can penetrate the enamel and dentin, and it can cause your proteins to break down. And smaller pieces are removed from those proteins."

She and her undergraduate students presented on that research at the 2019 Experimental Biology meeting in Orlando. [Keenan et al., (abstract 1), (abstract 2) and (abstract 3)]

This is just a preliminary study for now, and the pulp of your teeth can replenish proteins in the dentin, though not the enamel—so it's unclear whether these effects would cause permanent damage in real, living teeth. One thing’s for sure: supplies of teeth for experiments seem to be plentiful. 

"I think I bought a set of 15. And the person's like, 'Let me know if you need more.' This person also claimed the teeth were from his mouth, which, you don't have that many more to go!" 

—Christopher Intagliata 

[The above text is a transcript of this podcast.]

Subscribe to Support Independent Journalism

Great science journalism requires human expertise, time, effort and creativity. And it costs money. That’s why I and the journalists here at Scientific American hope you’ll join our community.

When you subscribe, you are supporting staff and freelance journalists who are passionate about telling science stories that are true, important and compelling. Our editors and reporters are often experts in their fields, which means they understand the nuances of big discoveries and can untangle the breakthroughs from the hype. With a subscription, you are also supporting rigorous fact-checking to ensure the words we publish are precise and accurate. And you’re supporting original illustrations, graphics and photos that bring you closer to an advanced laboratory, an ice sheet in Antarctica or a space mission in orbit. You’re helping us craft other types of high-quality journalism as well: Our newsletters are carefully written, edited and curated by staffers you have or will come to know and love. Our Science Quickly podcast is based on original reporting, collaboration with editors and scientists and exacting production.

Subscriptions keep this engine running so we can continue to deliver thoughtful, rigorous and independent science journalism to you. In an era of viral misinformation, this work is crucial. If you value what we do, I hope you’ll consider joining us as a subscriber

Thank you,

Jeanna Bryner, Editor in Chief, Scientific American

Subscribe