Ask The Experts

Join Our Community of Science Lovers!

Are food cravings the body’s way of telling us that we are lacking nutrients?

—J. SHELTON, OGDEN, UTAH

Peter Pressman of the Cedars-Sinai Medical Center in Beverly Hills, Calif., and Roger Clemens of the University of Southern California School of Pharmacy explain:


On supporting science journalism

If you're enjoying this article, consider supporting our award-winning journalism by subscribing. By purchasing a subscription you are helping to ensure the future of impactful stories about the discoveries and ideas shaping our world today.


A hankering for particular foods is not linked to any obvious nutrient insufficiency. But other biological factors appear to be at work.

Researchers have employed functional magnetic resonance imaging (fMRI) to explore the neural basis of such appetites. The images suggest that when somebody is pining for a certain fare, brain components in the amygdala, anterior cingulate, orbital frontal cortex, insula, hippocampus, caudate and dorsolateral prefrontal cortex are activated. A network of neural regions may be involved with the emotion, memory and chemosensory stimuli of food yens.

Desire for chocolate offers an example. The treat’s constituents may influence satiation or alter our longing for it by affecting mood-influencing chemicals in the brain, such as phenylethylamine, tyramine, serotonin, tryptophan and magnesium.

Additional factors such as simple carbohydrate content may amplify a food’s appeal or even attenuate depression. More support for a nutrition-neurological connection comes from research that shows that administration of naloxone, an agent that blocks opiate receptors in the brain, appears to inhibit the consumption of sweet, high-fat foods—chocolate among them. Studies of cannabinoids, which commonly occur in marijuana, have shed more light on the neurochemistry of selective appetite. In addition, research has identified an entire spectrum of gut neuropeptides with elaborate central nervous system feedback and influence on satiety.

Some studies suggest that chocolate craving, especially among women, may partly result from a sense of deprivation or a reaction to stress, hormonal fluctuation and modulation of neuropeptide concentrations. Culture has an influence as well. Spanish women, for example, eat relatively large quantities of chocolate and exhibit limited craving for that sweet. In contrast, American women consume less yet present a strong “chocophilic” tendency.

What causes feedback in a guitar or microphone?

Robert L. Clark of the Pratt School of Engineering at Duke University offers this answer:

Several mechanisms can lead to the unpleasant shriek known as feedback. Let us deal first with the simple case of a microphone and an amplified speaker. Feedback occurs when a “loop” closes between an input (the microphone) and output (the amplified speaker). The sound radiated from the amplified speaker reaches the microphone and is subsequently amplified again and again, until it saturates and can no longer amplify the input. This excessive ratio of output to input, called gain, occurs at a particular frequency and arises from many factors. These can include the distance between the microphone and the speaker, the directional design of the microphone and speaker, the influence of reflective surfaces within the acoustic environment, and the presence of additional microphones and amplified speakers. To reduce gain, an equalizer can adjust the signal amplification.

When a microphone is used with an acoustic guitar, the amplified speaker closes the loop between the input and output when the radiated sound from the speaker reaches the guitar. In such cases, the guitar starts vibrating excessively at a particular frequency (typically between 100 and 200 hertz), or the room itself can begin to resonate, producing an audible tone. A similar mechanism occurs in electric guitars. Structural vibrations induced by acoustic feedback can magnify the signal generated by sensors embedded in the guitar to “pick up” its sound, leading to the instability of feedback.

Scientific American Magazine Vol 293 Issue 3This article was published with the title “Ask The Experts” in Scientific American Magazine Vol. 293 No. 3 (), p. 124
doi:10.1038/scientificamerican0905-124

It’s Time to Stand Up for Science

If you enjoyed this article, I’d like to ask for your support. Scientific American has served as an advocate for science and industry for 180 years, and right now may be the most critical moment in that two-century history.

I’ve been a Scientific American subscriber since I was 12 years old, and it helped shape the way I look at the world. SciAm always educates and delights me, and inspires a sense of awe for our vast, beautiful universe. I hope it does that for you, too.

If you subscribe to Scientific American, you help ensure that our coverage is centered on meaningful research and discovery; that we have the resources to report on the decisions that threaten labs across the U.S.; and that we support both budding and working scientists at a time when the value of science itself too often goes unrecognized.

In return, you get essential news, captivating podcasts, brilliant infographics, can't-miss newsletters, must-watch videos, challenging games, and the science world's best writing and reporting. You can even gift someone a subscription.

There has never been a more important time for us to stand up and show why science matters. I hope you’ll support us in that mission.

Thank you,

David M. Ewalt, Editor in Chief, Scientific American

Subscribe